Nov 19, 2013 · Chronic lymphocytic leukemia (CLL) is characterized by a typical defect in apoptosis and is still an incurable disease. Numerous apoptosis inducers have been described. These synthetic compounds and natural products (mainly derived from plants) display antileukemic properties in Cited by: 21.
Hairy cell leukemia is an uncommon hematological malignancy characterized by an accumulation of abnormal B lymphocytes. It is usually classified as a sub-type of chronic lymphocytic leukemia (CLL). Hairy cell leukemia makes up approximately 2% of all leukemias, with fewer than 2,000 new cases diagnosed annually in North America and Western Europe combined.Specialty: Hematology and oncology.
Feb 14, 2014 · Hairy cell leukemia (HCL) is part of the low-grade non-Hodgkin lymphoma family and represents approximately 2% of all leukemias. Treatment with splenectomy and interferon-α historically belonged to the first steps of therapeutic options, achieving partial responses/remissions (PR) in most cases with a median survival between 4 and 6 years in the 1980s.Cited by: 24.
Lymphocyte populations show a defect to undergo induced apoptosis in vitro, which points to the pathogenesis of the disease. Upon binding of Fas ligand to Fas on the lymphocyte cell surface, signal transduction occur through caspases, leading to the cell and nuclear changes that are characteristic of apoptosis.